Understanding the Science Behind Skin Aging and Wound Repair

As our body’s largest organ and outermost protective barrier, our skin undergoes constant assaults from both internal and external forces alike, ranging from malnutrition and disease to ultraviolet radiation and environmental pollution. Most notably, though, the aging process seems to share many similarities with the body’s healing of injuries, as both heavily involve the skin’s intrinsic repair mechanisms. When we sustain a wound, our body undergoes a three-stage healing process: inflammation, regeneration, and remodeling. However, as we get older, this process slows down, extending the time it takes to heal the damages caused. As aging leads to a decline in the number of stem cells—the powerhouse cells responsible for physiological restoration—produced, it makes the skin less efficient at defending and repairing itself over time.

Stem cells, with their unique abilities to create multiple cell types with different functions, play a crucial role in speeding up wound healing and skin regeneration. These cells communicate with their surrounding counterparts by sending out instructive signals, reducing inflammation, encouraging cell renewal, and contributing to the skin’s structural layers. It’s an impressive and essential repair system that our bodies have in place, but like everything else, it’s not immune to the wear and tear of time. It can’t be understated, then, that regularly boosting stem cell activity is necessary to maintaining optimal skin function.

In response to this inevitable deterioration in stem cell activity, CALECIM® Professional skincare presents an innovative approach involving stem cell technology that offers a potent source for stimulating tissue renewal through cell-to-cell communication. The proprietary active ingredient, called PTT-6®, is derived from this and aims to trigger the skin to rebuild layers, boost epidermal surface renewal, and enhance hydration. It was found through studies conducted with the National University of Singapore that stem cell wound-healing technology, like the type employed by CALECIM®, is inherently anti-aging. By augmenting cells responsible for intrinsic repair and modifying the cellular environment to facilitate repair, this technology aligns with the principles of combating skin aging.

Clinical trials have shown dramatic results in patients’ skin volume and facial contours, attributing improvements to CALECIM® Professional’s unique cell signaling technology, that help to strengthen the skin from within. Tests show that users experience a 600% average improvement in skin thickness, 42% more skin cell growth within seven days, and complete skin restoration in 40 hours.

In another clinical observation conducted by Dr. Ziv Peled, a plastic surgeon, results from using the Multi-Action Cream, a stem cell skincare product, were observed within two weeks. Improved complexion, increased skin tone and fullness, a lifting effect, tighter jawline, elevated eyebrows, and enhanced facial definition were among the notable improvements reported across various ages and skin types.

Beyond stem cells, growth factors and exosomes are pivotal components in skincare. The former are proteins secreted by various skin calls and support the repair of damaged skin by activating collagen and elastin production. Exosomes, meanwhile, are tiny sac-like structures that hold and contain growth factors, and their role is to facilitate communication between cells. Altogether, these are essential components for combatting lines, wrinkles, skin inflammation, and hyperpigmentation.

Cosmetic surgeon and dermatologist Dr. Mitchel Goldman explains that growth factors signal skin cells, particularly fibroblasts responsible for collagen production, to rejuvenate. As the aging skin manufactures fewer growth factors, products with high concentrations of stable growth factors, especially those derived from stem cell cultures, become essential for skin revival.

There are various methods used to produce and supply growth factors and exosomes, including from human cells, bioengineering from non-human sources, and synthetic reproduction. As a brand, CALECIM® stands out by utilising ethically sourced stem cells as the richest source of its kind within the human body. The technology involves cultivating stem cells in a lab, resulting in the creation of the ingredient PTT-6®, a highly concentrated mix of 3,000 active growth factors, proteins, and cytokines that make it the most concentrated and powerful growth factor in the skincare world.

PTT-6® is a key active ingredient in all CALECIM® Professional products, and works by sending protein messages to all skin layers. It enhances collagen and elastin production, increases skin density, and shortens epidermal cell turnover time, resulting in a skin-tightening and lifting effect. The ultimate objective of CALECIM®’s products is not merely to make individuals look younger but to make their skin behave younger. The unique cell trigger technology, highlighted for its rejuvenating and renewing properties, positions the brand as a pioneer in skincare innovation.

Described as a corrective treatment, their Multi-Action cream targets signs of premature aging, including volume loss, sagging, and loss of facial contours. The hydrating and firming proteins are activated within the epidermis by the stem cells’ strong mix of growth factors and exosomes, triggering a regeneration of the skin layers and boosting its rejuvenation properties. Dr. Ziv Peled’s clinical observations attest to the cream’s effectiveness in improving complexion, skin tone, and overall definition in facial aesthetics, with such visible benefits noted in as little as two weeks.

CALECIM®’s Restorative Hydration Cream further boosts hydration to the skin by amplifying the natural secretion of hyaluronic acid within the epidermis, bringing it to optimal levels. When applied to skin that feels chronically dry or tired, it hydrates and plumps it up by minimising fine lines and improving any visible hollowness. Similar to the Multi-Action cream, it is designed with a transepidermal formulation, which just means that the growth factors in the PTT-6® ingredient work to interact with every layer in the skin and reach deep.

An advantage of CALECIM® Professional products is their compatibility with existing skincare regimens. As a base layer, they allow the incorporation of other active ingredients like retinoids, AHA’s, and antioxidants. It’s the flexibility that ensures users can seamlessly integrate the core products into their established skincare routines.

In conclusion, the synergy of stem cells, growth factors, and exosomes in CALECIM®’s stem cell skincare range presents a transformative approach to improving skin health. By understanding and harnessing the natural mechanisms of the skin repair process, CALECIM® offers an ethical and effective solution for addressing signs of aging and promoting enduring skin vitality.